Dr. Jacob Vadakekalam is a Board-Certified Endocrinologist, with an expertise in several areas, including Type 2 diabetes mellitus, obesity, diseases of thyroid and the pituitary and osteoporosis. After receiving his Bachelor of Medicine and Bachelor of Surgery from St. John’s Medical College in Bangalore in 1981, he received his degree of Doctor of Medicine from Trivandrum Medical College, Kerala in 1986. He completed his Residency in Internal Medicine at the Mayo Graduate School of Medicine in June 1993. He completed his Fellowship in Endocrinology 1995 from the University of Wisconsin. He joined the Diabetes & Glandular Disease Clinic in San Antonio, Texas in March 2000.
Fellowship – University of Wisconsin July 1993 – June 1995
Residency – Mayo Graduate School of Medicine, Rochester, NM June 1991 – July 1993
Medical School – Bangalore University, August 1975 – March 198
Endocrine Certification in Neck Ultrasound (ECNU)
Fellow of American College of Endocrinology
Certification in Bone Densitometry
American Board of Endocrinology
American Board of Internal Medicine
M.R.C.P. London, U.K.
M.B.B.S. Bangalore, India
Texas – 1999 – Active
Washington – 1996 – Inactive
Wisconsin – 1993 – Active
Scientific Society Memberships
Texas Medical Association
Bexar County Medical Society
Washington State Medical Society
American Medical Association
American Diabetes Association
American College of Clinical Endocrinology
European Association for the Study of Diabetes
Mar 2000 – Present Diabetes & Glandular Disease Clinic, San Antonio, TX
Nov 1996 – Mar 2000 Endocrine Consultants, NW, Tacoma WA
Effects of Exenatide on Glycemia, C-Reactive Protein and Weight in Patients Taking a Thiazolidinedione and Other Anti-Diabetic Drugs. William F. Trigoso, TM Copple, J. Vadakekalam – Diabetes, 2007 – search.ebscohost.com
Impact of Use of Insulin, Glargine, on Hbg A1c and BMI in a Specialty (Endocrine) Practice Population. Jerome S. Fischer, M.D. Riad G. Dirani, M.D., Sherwyn L. Schwartz, M.D., Mark S. Kipnes, M.D., Fernando W. Trigoso, M.D., Amna A. Salhin, M.D., Jacob Vadakekalam, M.D., Daina Dreimane, M.D., Litza Loza, San Antonio, Texas. For presentation at the American Diabetes Association 62nd Scientific Sessions, San Francisco, California – 2002
A Defect Late in Stimulus-secretion Coupling Impairs Insulin Secretion in Goto-Kakizaki Diabetic Rats. Metz, M.; Meredith, J.; Vadakekalam, J.; Rabaglia, M. Diabetes, 1999: 28; pp. 1754-62
Isotopic Efflux Studies as Indices of Phopholipase Activation. J. Vadakekalam and S. Metz. Methods in Molecular Biology, 1998: 105; pp. 175-185
Interleukin-1 Inhibits Phospholipase-C and Insulin Secretion at Sites Apart From K+ (ATP) Channel. J. Vadakekalam; M. Rabaglia and S. Metz. Americal Journal Physiology, 1997: 273; pp. E942-E950
Interleukin-1 Inhibits Phospholipase-C Activation in Normal Rat Pancreatic Islets by Mechanisms Distal to the K+ (ATP) Channel. J. Vadakekalam; M. Rabaglia and S. Metz. Diabetes, 1997: 46; p 359A
Roles of GTP and Phospholipase-C in the Potentiation of Calcium-Induced Insulin Secretion by Glucose in Rat Pancreatic Islets. J. Vadakekalam; M. Rabaglia and S. Metz. Journal of Endocrinology, 1997: 153; pp. 61-71
GTP-Dependent Stimulation of The Membrane Association and Carboxyl Methylation of CDC42 in Rodent and Human Pancreatic Islets and Pure Beta Cell: Evidence For an Essential Role in Nutrient-Induced Insulin Secretion. A. Kowluri; S. Seavey; R. Sorenson; A.J. Weinhaus; R. Nesher; G. Li; M. Rabaglia; J. Vadakekalam and S. Metz. Journal of Clinical Investigation, 1996: 98; pp. 540-555
Glucose-Induced Phosphoinositide Hydrolysis: A Requirement for GTP in Calcium-Induced Phospholipase-C Activation in Pancreatic Islets. J. Vadakekalam; M. E. Rabaglia; Q-H Shen and S. Metz. American Journal of Physiology, 1996: 271; pp. E85-E95
Glucose-Induced Phospholipase-C Activation is Dependent on GTP in Pancreatic Islets. J. Vadakekalam; M. Rabaglia and S. Metz. Diabetologia, 1995:38 (supplement 1); p. 117A
A Requirement for GTP in Glucose and Calcium-induced Phospholipase-C Activation in Pancreatic Islets. J. Vadakekalam; M. Rabaglia and S. Metz. Diabetes, 1995: 44 (supplement 1); p. 189A
A Requirement for GTP in Glucose-Induced Phosphoinositide Hydrolysis. J. Vadakekalam; M. Rabaglia and S. Metz. Journal of Investigative Medicine. 1995:43; p. 170A
Clinical Management of the NIDDM Patient: Impact of the American Diabetes Association Practice Guidelines, 1985-1993. M. Stolar; The Endocrine Fellows Foundation Study Group. Diabetes Care, 1995:18; P. 701.
GTP-Binding Proteins in the Cell: Regulation and Effects on Insulin Secretion. Proceedings of 15th International Diabetes Federation, Kobe, Japan 1995. S. Metz; M. Meredith; J. Vadakekalam and A. Kowluru. Diabetes 1994, Elsevier Science B.V. pp. 228-234
Clinical Case Seminar; Sometimes the Hooves do Belong to Zebras! An Unusual Case of Hypopituitarism. J. Vadakekalam; T. Stamos and Y. Shenkar. Journal of Clinical Endocrinology & Metabolism, 1995: 80; P. 17
Apoptosis – An Alternative Mechanism of Bile Salt Hepatotoxicity. In. Paumgartner G, Beuers U, eds. Bile Acids in Liver Diseases. T. Patel; J. Spivey; J. Vadakekalam and G. J. Gores. Kluwer Academic Publishers, Lancaster, England. Chapter 9:88
Ursodeoxycholate Cytoprotection Against Hepatocyte Killing by Hydrophobic Bile Salts Cannot be Explained Solely by Changes in the Hydrophobic Index. J. R. Spivey; J. Vadakekalam and G. J. Gores. HepatologyHepatology 1992 16:134A
Complications of Laparoscopic Cholecystectomy: Perspective From a Referral Unit. J. Vadakekalam and A. J. Czaja. Gastrointestinal Endoscopy 1992, 38:282
Mycobacterium Fortuitum Lung Abscess Treated with Ciprofloxacin. J. Vadakekalam and M. J. Ward. Thorax 1991, 46:737
Virtual Endocrinologist: Hospital Diabetes Management Via Telemedicine. Mark S. Kipnes,1 Steve Haffner,2 Teri Lightner,3 Rajesh Garg,4 Firas Akhrass,5 Vijayveer S. Pamar,6 Amna a. Salhin,7Jacob Vadakekalam,8 Javier Pena,9 Syndy Kirkland,10 Merri Pendergrass,11. 1 DGD Clinic, San Antonio, TX; 2 San Antonio, TX; 3 See My DOC, Harlington, TX; 4 Harvard Medical School, Boston, MA; 5 DGD Clinic, San Antonio, TX; 6 DGD Clinic, San Antonio, TX; 7 DGD Clinic, San Antonio, TX; 8 DGD Clinic, San Antonio, TX; 9 VENP, Harlingen, TX; 10 VENP, Harlingen, TX; 11 University of Arizona, Tucson, AZ. Abstract presented at the ADA 76th Scientific Sessions New Orleans, LA June 10-14, 2016.
Long Term Effect of Glitazones in Clinical Practice. William F. Trigoso, Jacob Vadakekalam, Sherwyn Schwartz, Jerome Fischer, Mark Kipnes, Amna Salhin, Daina Dreimane, Litza Loza. San Antonio, TX, United States. Presentation at the ADA Annual Meeting & Scientific Sessions. 2002.
COMMUNITY SCREENING FOR DIABETES: SHOULD DEMOGRAPHICS BE A FACTOR? Mark S. Kipnes; Sherwyn L. Schwartz; Jerome S. Fischer; William F. Trigoso; Amna A. Salhin; Jacob Vadakekalam; Daina Dreimane and William D. Linn. Abstract submitted to the American Association of Clinical Endocrinologists 10th Annual Meeting & Clinical Congress. May 2-6, 2001. San Antonio, Texas.
Stimulation by Glucose of Carboxyl Methylation of Specific GTP-Binding Proteins in Pancreatic Beta Cells. A. Kowluri; S. Seavey; G. Li; J. Vadakekalam and S. Metz. Abstract submitted to the 10th International Congress of Endocrinology, June 12-15, 1996, San Francisco, CA. International Congress of Endocrinology, 1996: Vol 11; p 745.
Role For GTP and Phospholipase-C in Potentiation of Calcium-Induced Insulin Secretion by Glucose in Rat Pancreatic Islets. J. Vadakekalam, M. E. Rabaglia and S. Metz. Abstract submitted to the American Diabetes Association meeting June 8-11, 1996, San Francisco, CA.
Pattern of Thyroid Cancers in Kerala. J. Vadakekalam and Mr. Roy. Abstract submitted for annual meeting of Association of Physicians, held in Allahabad, India, January 1986.
Thyroid Carcinomas in Kerala. J. Vadakekalam. M.D. Thesis accepted by University of Kerala, 1986.
Impact of Use of Insulin, Glargine, on Hbg A1c and BMI in a Specialty (Endocrine) Practice Population. Jerome S. Fischer, M.D. Riad G. Dirani, M.D., Sherwyn L. Schwartz, M.D., Mark S. Kipnes, M.D., Fernando W. Trigoso, M.D., Amna A. Salhin, M.D., Jacob Vadakekalam, M.D., Daina Dreimane, M.D., Litza Loza, San Antonio, Texas. For presentation at the American Diabetes Association 62nd Scientific Sessions, June 14-18, 2002, San Francisco, California.